Specifications
Immunogen
Recombinant full length protein corresponding to Human Bid aa 1-195. Produced in HEK293T cells.Sequence: MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQ WEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRS IPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTM
Applications
Application Notes
WB: 1/2000; IHC-P: 1/150; ICC/IF: 1/100;
Target
Alternative Names
BID; BH3 interacting domain death agonist; BH3-interacting domain death agonist; p22 BID; BID isoform Si6; BID isoform L(2); BID isoform ES(1b); desmocollin type 4; apoptic death agonist; Human BID coding sequence; FP497; MGC15319; MGC42355;
Product Background
Antigen Description
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
Pathway
Activation and oligomerization of BAK protein, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem; Activation, translocation and oligomerization of BAX, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Citations
Publication ()
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