Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.
Pathway
Adherens junction; CDC42 signaling events; ErbB1 downstream signaling; RAC1 signaling pathway; Regulation of Actin Cytoskeleton; Regulation of actin cytoskeleton;
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