Anti-AXIN1 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

AXIN1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human AXIN1.

Conjugate

Alternative Names

AXIN1; axin 1; AXIN; PPP1R49; axin-1; axis inhibitor 1; fused, mouse, homolog of; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

Pathway

AMER1 mutants destabilize the destruction complex; APC truncation mutants are not K63 polyubiquitinated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; AXIN mutants destabilize the destruction complex; Basal cell carcinoma; Beta-catenin phosphorylation cascade; C-MYC pathway