General Notes
This product (Catalog No. DPABH-25054) is a rabbit-derived polyclonal antibody raised against human AXIN1, targeting the amino acid region 653–862 of the protein. This antibody exhibits cross-reactivity with Human AXIN1 from mouse and rat. It has been affinity purified by Protein A. AXIN1 is a protein-coding gene located on chromosome 16p13.3 that encodes axin-1, a multifunctional cytoplasmic scaffold protein essential for regulating the canonical Wnt/β-catenin signaling pathway. The axin-1 protein, consisting of 862 amino acids, features key structural domains including a regulator of G-protein signaling (RGS) domain for protein interactions and a dishevelled and axin (DIX) domain that facilitates polymerization and scaffolding functions. Discovered in 1997 through studies on the mouse fused locus, AXIN1 was identified as a negative regulator of Wnt signaling, inhibiting embryonic axis formation in vertebrates such as mice and frogs.
DPABH-25054 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-25054 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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