Anti-ATP6V1F (aa 10-119) polyclonal antibody

Species Reactivity

Human

Immunogen

ATP6V1F (NP_004222, 10 a.a. ~ 119 a.a) partial recombinant protein with GST tag. The sequence is VIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQY IAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR

Conjugate

Alternative Names

ATP6V1F; ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F; VATF; Vma7; ATP6S14; V-type proton ATPase subunit F; V-ATPase F subunit; V-ATPase subunit F; ATPase, vacuolar, 14 kD; V-ATPase 14 kDa subunit; vacuolar proton pump F subunit; vacuolar proton

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein.

Pathway

Collecting duct acid secretion; Disease; Epithelial cell signaling in Helicobacter pylori infection; Iron uptake and transport