Anti-ATP2A1 (aa 522-612) polyclonal antibody

Species Reactivity

Human

Immunogen

ATP2A1 (NP_775293, 522 a.a. ~ 612 a.a) partial recombinant protein with GST tag. The sequence is IDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDS ARFLEYETDLTFVGVVGMLDPPRKEVTGSIQ

Conjugate

Alternative Names

ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATP2A; SERCA1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasm

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.

Pathway

Alzheimers disease; Calcium signaling pathway; Ion channel transport; Pancreatic secretion