Anti-ASNA1 (aa 322-333) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide: C-PHEVRGADKVNT, corresponding to internal sequence amino acids 322-333 of Human ASNA1 (NP_004308.2)

Conjugate

Application Notes

Peptide Antibody detection limit dilution 1/2,000. WB: Use at a concentration of 0.3 - 1 μg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).

Alternative Names

ASNA1; arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); arsA (bacterial) arsenite transporter, ATP binding, homolog 1; ATPase ASNA1; ARSA I; GET3; golgi to ER traffic 3 homolog (S. cerevisiae); transmembrane domain recognition complex; 40kDa

Entrez Gene ID

UniProt ID

Antigen Description

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.