Anti-ASNA1 monoclonal antibody, clone BU3B2

Antibody Isotype

IgG2b

Clone

BU3B2

Species Reactivity

Human

Immunogen

Recombinant full length protein corresponding to Human ASNA1 aa 1-348. NP_004308. Purified from E. coli.Sequence: MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGK TTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNL FAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAF

Conjugate

Application Notes

WB: 1/1000;

Alternative Names

ASNA1; arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); arsA (bacterial) arsenite transporter, ATP binding, homolog 1; ATPase ASNA1; ARSA I; GET3; golgi to ER traffic 3 homolog (S. cerevisiae); transmembrane domain recognition complex; 40kDa

Entrez Gene ID

UniProt ID

Antigen Description

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.