Anti-ARRDC3 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide derived from the C-terminal of human ARRDC3.

Conjugate

Application Notes

ICC/IF: 5 μg/ml; WB: 1/500 - 1/1000; ELISA: 1/20000; IHC-P: 5 μg/ml;

Alternative Names

ARRDC3; arrestin domain containing 3; TLIMP; arrestin domain-containing protein 3; alpha-arrestin 3; TBP-2-like inducible membrane protein; thioredoxin-binding protein-2-like inducible membrane;

Entrez Gene ID

UniProt ID

Antigen Description

The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways.