ARHGEF4 (NP_056135, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. The sequence is MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVK
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; GPCR downstream signaling; Regulation of Actin Cytoskeleton; Rho GTPase cycle
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