Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. ARHGEF3 encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in ARHGEF3 plays a role in the determination of bone mineral density (BMD), suggesting a role in postmenopausal osteoporosis.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; G alpha (12/13) signalling events; GPCR downstream signaling; NRAGE signals death through JNK; Regulation of RhoA activity; Rho GTPase cycle; Signal Transduction
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