Rabbit Anti-Human ARHGEF3 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from internal of human ARHGEF3.

Conjugate

Application Notes

WB: 1:500-1:3000

General Notes

This product (Catalog No. DPABH-02161) is a rabbit-derived IgG polyclonal antibody raised against human ARHGEF3. This antibody exhibits cross-reactivity with ARHGEF3 from mouse. It has been affinity purified by protein A. Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
DPABH-02161 is suitable for use in Western blot (WB) (1:500–1:3,000) application.
DPABH-02161 is supplied as a liquid formulation in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

ARHG3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; GEF3; MGC118905

Entrez Gene ID

UniProt ID