ARHGEF2 (NP_004714, 590 a.a. ~ 690 a.a) partial recombinant protein with GST tag. The sequence is MTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELL LTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRAD
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Pathway
Cell death signalling via NRAGE, NRIF and NADE; GPCR downstream signaling; Pathogenic Escherichia coli infection; Regulation of RAC1 activity
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