Anti-ARHGEF16 monoclonal antibody (DCABH-4347)

Rabbit anti-Human ARHGEF16 monoclonal antibody for WB, IHC-P, ICC/IF, FC

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS0061
Species Reactivity
Mouse, Human
Immunogen
Synthetic peptide corresponding to residues in Human Rho guanine exchange factor 16 (UniProt Q5VV41).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; IHC-P: 1/50 - 1/100; ICC/IF: 1/100 - 1/250; Flow Cyt: 1/10 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ARHGEF16; Rho guanine nucleotide exchange factor (GEF) 16; rho guanine nucleotide exchange factor 16; GEF16; NBR; putative neuroblastoma protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARHGEF16 (Rho Guanine Nucleotide Exchange Factor 16) is a Protein Coding gene. Diseases associated with ARHGEF16 include frontal sinusitis. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include PDZ domain binding and receptor tyrosine kinase binding. An important paralog of this gene is ARHGEF15. Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions.
Antigen Description
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. The function about ARHGEF16 antigen include PDZ domain binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; protein binding; receptor tyrosine kinase binding.
Pathway
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; NRAGE signals death through JNK, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem.

Citations


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