The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene.
Pathway
Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Arf1 pathway, organism-specific biosystem; COPI Mediated Transport, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Endocytosis, organism-specific biosystem;
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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CAVENAGH, MM; BREINER, M; et al. ADP-RIBOSYLATION FACTOR (ARF)-LIKE-3, A NEW MEMBER OF THE ARF FAMILY OF GTP-BINDING PROTEINS CLONED FROM HUMAN AND RAT-TISSUES. JOURNAL OF BIOLOGICAL CHEMISTRY 269:18937-18942(1994).
Yu, S; Roth, MG; et al. Casein kinase I regulates membrane binding by ARF GAP1. MOLECULAR BIOLOGY OF THE CELL 13:2559-2570(2002).
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