Anti-ARFGAP1 monoclonal antibody, clone FQS24761

Antibody Isotype

IgG

Clone

FQS24761

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant fragment within Human ARFGAP1 aa 300 to the C-terminus. The exact sequence is proprietary.Database link: Q8N6T3

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/500.

Alternative Names

ARFGAP1; ADP-ribosylation factor GTPase activating protein 1; ADP ribosylation factor 1 GTPase activating protein , ARF1GAP; ADP-ribosylation factor GTPase-activating protein 1; bA261N11.3; FLJ10767; ARF1 GAP; ARF GAP 1; GAP protein; ARF1-directed GTPase-

Entrez Gene ID

UniProt ID

Antigen Description

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and RNP24. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.

Pathway

Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Arf1 pathway, organism-specific biosystem; COPI Mediated Transport, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Endocytosis, organism-specific biosystem;