Anti-ARF1 monoclonal antibody, clone 5H7

Antibody Isotype

IgG2a

Clone

5H7

Species Reactivity

Human

Immunogen

ARF1 (AAH11358.1, 1 a.a. ~ 181 a.a) full-length recombinant protein with GST tag.

Conjugate

Alternative Names

ARF1; ADP-ribosylation factor 1;

Entrez Gene ID

UniProt ID

Antigen Description

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

Pathway

Arf1 pathway, organism-specific biosystem; Arf6 downstream pathway, organism-specific biosystem; COPI Mediated Transport, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; Clathrin derived vesicle budding, organism-specific biosystem; Disease, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem;