Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Pathway
Activated NOTCH1 Transmits Signal to the Nucleus; Alzheimers disease; Cell death signalling via NRAGE, NRIF and NADE; Delta-Notch Signaling Pathway; NRIF signals cell death from the nucleus; Notch signaling pathway;
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