Human APH1A blocking peptide (CDBP0426)

Synthetic Human APH1A blocking peptide for BL

Product Overview
Blocking peptide for anti-APH1 antibody
Target
APH1
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Function
endopeptidase activity; protein binding;
Synonyms
APH1A; APH1A gamma secretase subunit; APH-1; APH-1A; CGI-78; 6530402N02Rik; gamma-secretase subunit APH-1A; aph-1alpha; presenilin-stabilization factor; anterior pharynx defective 1 homolog A;

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References


Peltonen, HM; Haapasalo, A; et al. Upsilon-Secretase Components as Predictors of Breast Cancer Outcome. PLOS ONE 8:-(2013).
Marlow, L; Canet, RM; et al. APH1, PEN2, and Nicastrin increase A beta levels and gamma-secretase activity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305:502-509(2003).

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