a peptide corresponding to amino acids near the amino-terminus of human Apaf1 The sequences of the immunogenic peptide are identical between human and mouse.
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Pathway
Activation of caspases through apoptosome-mediated cleavage; Alzheimer's disease; Alzheimers Disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Apoptosis Modulation and Signaling; Apoptosis Modulation by HSP70; Apoptotic factor-mediated response
Citations
Publication ()
Have you cited DPAB-L20071 in a publication? Let us know and earn a reward for your research.
My Review for Anti-APAF1 (N-terminal) polyclonal antibody
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Publication 
Loading ......
