Human APAF1 blocking peptide

Product Overview

Apaf 1 ( N - term ) peptide ( human )

Target

APAF1

Nature

Synthetic

Tag/Conjugate

Unconjugated

Concentration

0.2 mg/ml

Buffer

Preservative: 0.1% Sodium Azide; Constituents: PBS, BSA

Preservative

0.1% Sodium Azide

Storage

Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.

Entrez Gene ID

Antigen Description

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Function

ADP binding; ATP binding; cysteine-type endopeptidase activator activity involved in apoptotic process; nucleotide binding; protein binding;

Synonyms

APAF1; apoptotic peptidase activating factor 1; apoptotic peptidase activating factor , apoptotic protease activating factor; apoptotic protease-activating factor 1; APAF 1; CED4; APAF-1; DKFZp781B1145;