Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
Pathway
Lysosome;
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Citations
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Newell-Litwa, K; Salazar, G; et al. Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles. MOLECULAR BIOLOGY OF THE CELL 20:1441-1453(2009).
Chen, CJ; Zou, XQ; et al. Characterization of AP3B2_v2, a novel splice variant of human AP3B2. DNA SEQUENCE 18:165-168(2007).
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