Anti-AOAH monoclonal antibody (DCABH-10533) Made to order

Rabbit anti-Human AOAH monoclonal antibody for WB, ELISA

View other AOAH antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human AOAH is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
AOAH; acyloxyacyl hydrolase (neutrophil); acyloxyacyl hydrolase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AOAH (Acyloxyacyl Hydrolase) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, acting on ester bonds and acyloxyacyl hydrolase activity. This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.
Antigen Description
Acyloxyacyl hydrolase (AOAH) is a 2-subunit lipase which selectively hydrolyzes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial endotoxins. AOAH may modulate host inflammatory responses to gram-negative bacterial invasion. The 2 subunits are encoded by a single mRNA. Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. Acyloxyacyl hydrolase, also known as AOAH, is a protein which in humans is encoded by the AOAH gene. Acyloxyacyl hydrolase (AOAH) is a 2-subunit lipase which selectively hydrolyzes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPSs, also called endotoxins). This action inactivates LPSs that are sensed by MD-2--Toll-like Receptor 4 (TLR 4) on animal cells. The enzymes 2 disulfide-linked subunits are encoded by a single mRNA. The smaller subunit is a member of the saposin-like (SAPLIP) proteins and the larger subunit is a GDSL lipase.

Citations


Have you cited DCABH-10533 in a publication? Let us know and earn a reward for your research.

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Ojogun, N; Kuang, TY; et al. Overproduction of Acyloxyacyl Hydrolase by Macrophages and Dendritic Cells Prevents Prolonged Reactions to Bacterial Lipopolysaccharide In Vivo. JOURNAL OF INFECTIOUS DISEASES 200:1685-1693(2009).
Shao, BM; Kitchens, RL; et al. Prolonged Hepatomegaly in Mice That Cannot Inactivate Bacterial Endotoxin. HEPATOLOGY 54:1051-1062(2011).

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket