Anti-ANAPC11 monoclonal antibody, clone 4G6

Antibody Isotype

IgG1

Clone

4G6

Species Reactivity

Human

Immunogen

Recombinant full length Human Apc11 (amino acids 1-196) produced in HEK293T cells (UniProt Q9NYG5-2).

Conjugate

Application Notes

WB: 1/4000; ICC/IF: 1/100; IHC-P: 1/150;

Alternative Names

ANAPC11; anaphase promoting complex subunit 11; anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase-promoting complex subunit 11; APC11; Apc11p; HSPC214; MGC882; cyclosome subunit 11; APC11 anaphase promoting complex subunit 11 homolog;

Entrez Gene ID

UniProt ID

Antigen Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Pathway

APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem;