Anti-AMPH monoclonal antibody, clone O9-3

Antibody Isotype

IgG1

Clone

O9-3

Species Reactivity

Human

Immunogen

Recombinant human protein purified from E.coli

Conjugate

Alternative Names

AMPH; amphiphysin; amphiphysin (Stiff Man syndrome with breast cancer 128kDa autoantigen) , amphiphysin (Stiff Mann syndrome with breast cancer 128kD autoantigen); amphiphysin I; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); AMP

Entrez Gene ID

UniProt ID

Antigen Description

Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.

Pathway

Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Internalization of ErbB1, organism-specific biosystem; Monoamine Transport, organism-specific biosystem;