Anti-AKR7A2 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant full length protein corresponding to Human AKR7A2 aa 1-359.Sequence: MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRR MDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRV KIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE ETLHACQRLHQEGKFVELGLS

Conjugate

Application Notes

IHC-P: 1/50 - 1/200; WB: 1/500 - 1/2000.

Alternative Names

AKR7A2; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); aflatoxin B1 aldehyde reductase member 2; AFAR; AFB1-AR 1; SSA reductase; aldoketoreductase 7; AFB1 aldehyde reductase 1; succinic semialdehyde reductase; aflatoxin beta1 alde

Entrez Gene ID

UniProt ID

Antigen Description

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Pathway

Metabolism of xenobiotics by cytochrome P450;