Knockdown of LINC00662 represses AK4 and attenuates radioresistance of oral squamous cell carcinoma
CANCER CELL INTERNATIONAL
Authors: Chen, Yangzong; Bao, Chunchun; Zhang, Xiuxing; Lin, Xinshi; Fu, Yimou
Abstract
Background LncRNAs play crucial roles in the development of carcinomas. However, the investigation of LINC00662 in Oral squamous cell carcinoma (OSCC) is still elusive. Methods qRT-PCR assay tested the expression levels of LINC00662, hnRNPC and AK4. With exposure to irradiation, CCK-8, colony formation, flow cytometry and western blot experiments, respectively determined the function of LINC00662 in the radiosensitivity of OSCC cells. Then RIP and western blot assays affirmed the interaction between hnRNPC protein and LINC00662 or AK4. Finally, rescue assays validated the regulation mechanism of LINC00662 in the radioresistance of OSCC. Results In the present report, LINC00662 was overexpressed in OSCC and its silencing could alleviate radioresistance of OSCC. Furthermore, the interaction between hnRNPC protein and LINC00662 or AK4 was uncovered. Besides, LINC00662 regulated AK4 mRNA stability through binding to hnRNPC protein. To sum up, LINC00662 modulated the radiosensitivity of OSCC cells via hnRNPC-modulated AK4. Conclusion The molecular mechanism of the LINC00662/hnRNPC/AK4 axis was elucidated in OSCC, which exhibited a promising therapeutic direction for patients with OSCC.
Effect of Grain Size on the Fracture Behavior of Aluminum Alloy AK4
METAL SCIENCE AND HEAT TREATMENT
Authors: Zhegina, I. P.; Morozova, L. V.
Abstract
The effect of grain size on the mechanical properties of aluminum alloy AK4 is studied. Comparative analysis of the fracture behavior and of the capacity for delaying crack propagation is performed for alloys with medium-size and fine grains.
COA
Publication 
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