Anti-AK3L1 monoclonal antibody, clone FQS8780

The corrosion rate was determined and corrosion damage features of the samples made of AK4-1 aluminum alloy were investigated in the NACE solution containing hydrogen sulfide (H2S). The alloy was investigated in the ultra-fine-grain state compared with the coarse-grain state formed after standard treatment T6 (quenching + ageing). The alloy was nanostructured by equichannel angular pressing (ECAP). It is shown that the alloy corrosion rate after ECAP is higher than after T6 treatment by a factor of 1.9. Herewith, the total corrosion takes place in alloy after ECAP, while pitting corrosion is also observed after T6 treatment in addition to the total corrosion. The corrosion effect strongly affects surface-roughness parameters of the samples made of AK4-1 alloy after ECAP compared with the samples after T6 treatment.

It is well known that motion of LID and NMP-binding (NMPbind) domains in adenylate kinase (AK) is important in ligand binding and catalysis. However, the nature of such domain motions is poorly characterized. One of the Critical hinge regions is hinge IV, which connects the CORE and LID domains. In addition, the hinge IV contains a strictly conserved residue. L171, in the AK family. To investigate the role of hinge IV. crystal Structure Of human adenylate kinase 4 (AK4) L171 P Mutant was determined. This mutation dramatically changes the orientation of the LID domain, which could be described as a novel twisted- and-closed conformation in contrast to the open and closed conformations in other AKs. This mutant provides a new example of domain motions in AK family. (C) 2008 Elsevier Inc. All rights reserved.