Anti-AGFG1 monoclonal antibody (DCABH-10453) Made to order

Rabbit anti-Human AGFG1 monoclonal antibody for WB, ELISA

View other AGFG1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human AGFG1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
AGFG1; ArfGAP with FG repeats 1; HIV 1 Rev binding protein , HRB; arf-GAP domain and FG repeat-containing protein 1; RAB; RIP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AGFG1 (ArfGAP With FG Repeats 1) is a Protein Coding gene. Diseases associated with AGFG1 include choroideremia and hiv-1. Among its related pathways are Influenza A. GO annotations related to this gene include RNA binding. An important paralog of this gene is AGFG2. The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. Arf-GAP domain and FG repeats-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. The function about AGFG1 antigen include ARF GTPase activator activity; DNA binding; RNA binding; metal ion binding; protein binding; zinc ion binding.
Pathway
Influenza A, organism-specific biosystem; Influenza A, conserved biosystem.

Citations


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References


Panaro, MA; Acquafredda, A; et al. Organization patterns of the AGFG genes: an evolutionary study. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 33:111-123(2011).
Kowalczuk, O; Burzykowski, T; et al. CXCL5 as a potential novel prognostic factor in early stage non-small cell lung cancer: results of a study of expression levels of 23 genes. TUMOR BIOLOGY 35:4619-4628(2014).

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