Synthetic peptide: C-RDAYREAQQLVQR, corresponding to internal sequence amino acids 648-660 of Human GRK2.
Conjugate
Unconjugated
Applications
Application Notes
ELISA: detection limit dilution 1/16000. WB: Use at a concentration of 0.3 - 1 μg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 80 kDa).
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Pathway
CXCR4-mediated signaling events; CaM pathway; Chemokine signaling pathway; DAG and IP3 signaling
Citations
Publication ()
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COA
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