Anti-ADRA1B (internal region) polyclonal antibody

Species Reactivity

Chicken; Dog; Human; Mouse; Pig; Rat

Immunogen

A synthetic peptide corresponding to internal region of human ADRA1B. The sequence is SSTKAKGHNPRSS

Conjugate

Application Notes

ELISA: 1:128000; WB: 0.1-0.3μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

ADRA1B; adrenoceptor alpha 1B; ADRA1; ALPHA1BAR; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; adrenergic, alpha-1B-, receptor;

Entrez Gene ID

UniProt ID

Antigen Description

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Pathway

AMPK signaling; Adrenergic signaling in cardiomyocytes; Amine ligand-binding receptors; Calcium signaling pathway.