Specifications
Species Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide corresponding to internal region of human ADH5. The sequence is C-KKIKVDEFVTHN
Applications
Application Notes
ELISA: 1:4000; WB: 0.5-1.5 μg/mL. & The optimal working dilution should be determined by the end user.
Target
Alternative Names
ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide; FDH; ADHX; ADH-3; FALDH; GSNOR; GSH-FDH; alcohol dehydrogenase class-3; formaldehyde dehydrogenase; alcohol dehydrogenase class-III; alcohol dehydrogenase class chi chain; S-(hydroxymethyl)glutat
Product Background
Antigen Description
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene.
Pathway
Carbon metabolism; Chemical carcinogenesis; Degradation of aromatic compounds; Drug metabolism - cytochrome P450
Citations
Publication ()
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COA
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