Synthetic peptide within Human ADAM17 aa 733-737 (phospho T735) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. Peptide sequence around phosphorylation site of Threonine 735Sequence: PQT(p)PG Database link: P78536
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/1000
Target
Alternative Names
ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumo
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
Pathway
Activated NOTCH1 Transmits Signal to the Nucleus; Alzheimers disease; Apoptosis; Collagen degradation
Citations
Publication ()
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