Anti-ADAM17 monoclonal antibody (DMABT-H12989)
Mouse anti-Human ADAM17 monoclonal antibody for WB, IHC, sELISA, ELISA
Datasheet
Specifications
Host Species
Mouse
Antibody Isotype
IgG2b
Clone
2G7
Species Reactivity
Human
Immunogen
ADAM17 (NP_003174, 215 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Target
Alternative Names
ADAM17; ADAM metallopeptidase domain 17; TACE, tumor necrosis factor, alpha, converting enzyme; disintegrin and metalloproteinase domain-containing protein 17; CD156B; cSVP
Entrez Gene ID
UniProt ID
Product Background
Pathway
Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Disease, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem;
Citations
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References
Mutsaers, AJ; Francia, G; et al. Dose-Dependent Increases in Circulating TGF-alpha and Other EGFR Ligands Act As Pharmacodynamic Markers for Optimal Biological Dosing of Cetuximab and Are Tumor Independent. CLINICAL CANCER RESEARCH 15:2397-2405(2009).
Lee, YJ; Lee, SH; et al. Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice. TOXICOLOGY AND APPLIED PHARMACOLOGY 263:61-72(2012).
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Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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