Synthetic peptide: QVDFNRRADSLQKNQ by a Cysteine residue linker, corresponding to internal sequence amino acids 129-143 of Human Aconitase 1 (NP_002188.1).
Conjugate
Unconjugated
Applications
Application Notes
WB: 0.1 - 0.3 μg/ml.
Target
Alternative Names
ACO1; aconitase 1, soluble; IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1; cytoplasmic aconitate hydratase; IRE-BP 1; citrate hydro-lyase; iron regulatory protein 1; ferritin repressor protein; epididymis luminal protein 60; aconitate hydratase, cytoplasmic; i
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
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