Human ACO1 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-ACO1/Aconitase 1 antibody

Target

ACO1 / Aconitase 1

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]

Function

4 iron, 4 sulfur cluster binding; RNA binding; RNA binding; aconitate hydratase activity; iron-responsive element binding; metal ion binding; protein binding;

Synonyms

ACO1; aconitase 1, soluble; IRP1; ACONS; HEL60; IREB1; IREBP; IREBP1; cytoplasmic aconitate hydratase; IRE-BP 1; citrate hydro-lyase; iron regulatory protein 1; ferritin repressor protein; epididymis luminal protein 60; aconitate hydratase, cytoplasmic; iron-responsive element binding protein 1; iron-responsive element-binding protein 1;