Anti-ABCB11 polyclonal antibody (DPABH-05135)

Rabbit Anti-Human ABCB11 (aa 474-745) polyclonal antibody for WB, IHC-P, ICC/IF Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to a region within internal amino acids 474-745 of Human ABCB11 (O95342).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ABCB11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump; BSEP; PFIC2; progressive familial intrahepatic cholestasis 2
Entrez Gene ID
UniProt ID

Product Background


Pathway
ABC transporters; Bile acid and bile salt metabolism; Bile secretion; Metabolism; Metabolism of lipids and lipoproteins;

Citations


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References


Keitel, V; Burdelski, M; et al. De Novo Bile Salt Transporter Antibodies as a Possible Cause of Recurrent Graft Failure After Liver Transplantation: a Novel Mechanism of Cholestasis. HEPATOLOGY 50:510-517(2009).
Maggiore, G; Gonzales, E; et al. Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type 2. JOURNAL OF HEPATOLOGY 53:981-986(2010).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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