Anti-ABCB11 (aa 1307-1321) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

A synthetic peptide (conjugated with KLH) corresponding to amino acids 1307-1321 of mouse Abcb11.

Conjugate

Application Notes

WB: 1:1000. & The optimal working dilution should be determined by the end user.

Alternative Names

ABCB11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; Bsep; PGY4; SPGP; ABC16; Lith1; PFIC2; bile salt export pump; sister of P-glycoprotein; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B, member 11;

Entrez Gene ID

UniProt ID

Antigen Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Pathway

ABC transporters; Bile acid and bile salt metabolism; Bile secretion; Metabolism of lipids and lipoproteins