Anti-ATP6V1D monoclonal antibody (DMABT-H13106)

Mouse anti-Human ATP6V1D monoclonal antibody for WB, IHC, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4H5
Species Reactivity
Human
Immunogen
ATP6V1D (NP_057078, 69 a.a. ~ 168 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D; ATP6M, ATPase, H+ transporting, lysosomal (vacuolar proton pump); V-type proton ATPase subunit D; VATD; VMA8
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ATP6V1D (ATPase H+ Transporting V1 Subunit D) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.
Antigen Description
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene. 0The function about ATP6V1D antigen include ATPase activity, coupled to transmembrane movement of substances; protein binding; proton-transporting ATPase activity, rotational mechanism.
Pathway
Collecting duct acid secretion, organism-specific biosystem; Collecting duct acid secretion, conserved biosystem; Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Insulin receptor recycling, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Metabolic pathways, organism-specific biosystem.

Citations


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References


Gao, K; Lockwood, WW; et al. Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 32:1343-1349(2008).
Sun, DM; Cheng, Y; et al. Quantitative Proteome of Medulla Oblongata in Spontaneously Hypertensive Rats. JOURNAL OF PROTEOME RESEARCH 12:390-395(2013).

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