Anti-ATP6V1D (aa 69-168) polyclonal antibody

Species Reactivity

Human

Immunogen

ATP6V1D (NP_057078, 69 a.a. ~ 168 a.a) partial recombinant protein with GST tag. The sequence is LAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGG EQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKITNRR

Conjugate

Alternative Names

ATP6V1D; ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D; VATD; VMA8; ATP6M; V-type proton ATPase subunit D; V-ATPase D subunit; V-ATPase subunit D; vacuolar H-ATPase subunit D; vacuolar proton pump D subunit; vacuolar proton pump subunit D; vacuol

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein.

Pathway

Collecting duct acid secretion; Disease; Epithelial cell signaling in Helicobacter pylori infection; Iron uptake and transport