Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
Function
antioxidant activity; cholesterol transporter activity; copper ion binding; lipid binding; phosphatidylcholine binding; phosphatidylcholine-sterol O-acyltransferase activator activity; protein homodimerization activity;
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