Human APBB1 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-APBB1/FE65 antibody

Target

APBB1 / FE65

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Function

beta-amyloid binding; beta-amyloid binding; chromatin binding; histone binding; proline-rich region binding; protein binding; transcription factor binding;

Synonyms

APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; FE65; MGC:9072; amyloid beta A4 precursor protein-binding family B member 1; stat-like protein; adaptor protein FE65a2;