Anti-APBB1 monoclonal antibody, clone 5I435

Antibody Isotype

IgG

Clone

5I435

Species Reactivity

Mouse

Immunogen

Fusion protein: DLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSS, corresponding to amino acids 254-293 of Mouse FE65 (WW domain).

Conjugate

Alternative Names

APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1; amyloid beta A4 precursor protein-binding family B member 1; Rir; Fe65;

Entrez Gene ID

UniProt ID

Antigen Description

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on Tyr-142 (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;