Human AIRE peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

AIRE peptide corresponds to 12 amino acids near the C-terminus region of AIRE.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Reconstitution

AIRE peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

Entrez Gene ID

Synonyms

AIRE; autoimmune regulator; APS1; APSI; PGA1; AIRE1; APECED; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein;