Human AIRE blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-AIRE (isoforms 1 and 2) antibody

Target

AIRE (isoforms 1 and 2)

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Gene ID

326

UniProt ID

O43918

Antigen Description

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).

Function

DNA binding; chromatin binding; histone binding; identical protein binding; metal ion binding; protein binding; transcription regulatory region DNA binding; translation regulator activity; zinc ion binding;

Synonyms

AIRE; autoimmune regulator; APECED, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); APS1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy; PGA1; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; APSI; AIRE1; APECED;