Progress in high strength intermediate modulus carbon fiber and its high toughness resin matrix composites in China
CAILIAO GONGCHENG-JOURNAL OF MATERIALS ENGINEERING
Authors: Bao Jian-wen; Zhong Xiang-yu; Zhang Dai-jun; Peng Gong-qiu; Li Wei-dong; Shi Feng-hui; Li Ye; Yao Feng; Chang Hai-feng
Abstract
High strength intermediate modulus carbon fiber composites are still the main aviation composites in the world at present and for a long time to come. In recent year, based on the experience of high-strength carbon fiber composites, the industrialization technology of high strength intermediate modulus 7800 grade carbon fiber have been broken through in China, and the resin matrix, prepreg and manufacturing process were analysized systematically for the high toughness composites reinforced by Chinese T800 grade carbon fiber. The impact resistance of the resin matrix composites reinforced by Chinese T800H grade carbon fiber is at the same level with that of foreign composites, and the hydrothermal resistance of high toughness epoxy resin matrix composites is better than that of foreign composites with the same CAI level. At the same time, the prepreg of Chinese T800H grade carbon fiber reinforced high toughness composites has excellent process ability, and it can meet the requirements of manual-layup, ATL and AFP. Based on the T800 grade composites, the main research goal is to improve the compression mechanical properties, elastic modulus and CAI based on BVID(barely visible impact damage) for high strength intermediate modulus carbon fiber composites in the future.
SEPT9 Gene Methylation as a Noninvasive Marker for Hepatocellular Carcinoma
DISEASE MARKERS
Authors: Li, Baoliang; Huang, Hao; Huang, Ronghai; Zhang, Wei; Zhou, Guangpeng; Wu, Zhen; Lv, Chunhua; Han, Xiaoliang; Jiang, Li; Li, Yongjun; Li, Baohua; Zhang, Zhongtao
Abstract
Background. Early detection appears to be the most effective approach to improve the overall survival of patients with hepatocellular carcinoma (HCC). We evaluated the potential performance of plasma SEPT9 methylation (mSEPT9) as a noninvasive biomarker for the diagnosis of patients with HCC. Methods. A total of 373 subjects were included, and the group consisted of 104 HCC patients, 95 with an at-risk disease, and 174 healthy controls (HC). The methylation of mSEPT9 was determined using methylation-specific fluorescence quantitative PCR. The diagnostic performance of plasma mSEPT9 for HCC was assessed in a single-blind manner. Results. The receiver operating characteristic (ROC) curve showed that plasma mSEPT9 can be used to detect and discriminate HCC with an area under the ROC curve (AUROC) of 0.961, a sensitivity of 82.7%, and specificity of 96.0% from HC. These results showed that plasma mSEPT9 had better diagnostic performance than serum alpha fetoprotein (AFP) (AUROC 0.881, sensitivity 57.7%, and specificity 98.3%). Similar results were noted in the detection of early-stage HCC. When combined with serum AFP, the sensitivity increased to 91.3% and 87.7% for the detection of HCC and early-stage HCC,respectively. Notably, the levels of plasma mSEPT9 dramatically decreased after surgery (P=0.001). Conclusions. Plasma SEPT9 methylation might serve as a useful and noninvasive biomarker for the diagnosis of HCC and can be used to evaluate the therapeutic efficacy of HCC treatment.