Human ACAT1 blocking peptide

Name: Human ACAT1 blocking peptide
SKU: CDBP0285
Rating: 5 (1 reviews)

Synthetic Human ACAT1 blocking peptide for Apuri, BL, ELISA

COA

SDS

Datasheet

Summary

Product Overview

Blocking/Immunizing peptide for anti-ACAT1 (aa257-269) antibody

Target

ACAT1 (aa257-269)

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Function

acetyl-CoA C-acetyltransferase activity; coenzyme binding; enzyme binding; metal ion binding; protein homodimerization activity; transferase activity, transferring acyl groups other than amino-acyl groups;

Synonyms

ACAT1; acetyl-CoA acetyltransferase 1; ACAT, acetyl Coenzyme A acetyltransferase 1; acetyl-CoA acetyltransferase, mitochondrial; acetoacetyl Coenzyme A thiolase; THIL; acetoacetyl-CoA thiolase; acetyl-Coenzyme A acetyltransferase 1; mitochondrial acetoacetyl-CoA thiolase; T2; MAT; ACAT;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Downregulation ofAcat1by miR-21 may participate in liver fibrosis upon chronic DDT exposure

TOXICOLOGY MECHANISMS AND METHODS

Authors: Chanyshev, Mikhail D.; Yarushkin, Andrey A.; Koldysheva, Elena, V; Lushnikova, Elena L.; Gulyaeva, Lyudmila F.

Abstract

The main objective of the present study was to investigate the toxic effect of long-term exposure to DDT (2,2-dichlorodiphenyl-1,1,1-trichloroethane) on rat livers. Female Wistar rats were treated with once-weekly i.p. doses of DDT (10 and 50 mg/kg) for 12 weeks. Histological analysis revealed significant changes in the liver structure, especially at a dose of 50 mg/kg, which consistent with a fibrotic state. Long-term DDT exposure increased micro RNA-21 (miR-21) level and decreased Acetyl-CoA acetyltransferase 1 (Acat1) mRNA and protein levels in a dose-dependent manner. A dual-luciferase reporter assay confirmed the regulation of the ratAcat13 '-UTR by miR-21. Previous studies have described the involvement of ACAT1 in fibrogenesis; thus, regulation of theAcat1gene by miR-21 may play a role in DDT exposure-mediated liver fibrosis.

ACAT1 is not associated with Alzheimer's disease in two independent family-based samples

MOLECULAR PSYCHIATRY

Authors: Bertram, L; Hsiao, M; Mullin, K; Parkinson, M; Menon, R; Moscarillo, TJ; Blacker, D; Tanzi, RE

Abstract