Specificity: Z22 binds both Z-DNA, but not B-DNA or ssDNA (single-stranded DNA). It recognizes Z-DNA at the phosphodiester backbone of various base sequences including (dG-dC)n. (dG-dC)n, (dTdG)n. (dC-dA)n, (dG-dme5C)n.(dG-dme5C)n and (dG-dbr5C)n.(dG-dbr5C)n. In other words, Z22 binds Z-DNA irrespective of sequence. Z22 Also binds DNA-8-MOP aducts and Z-RNA.
Application: EMSA, IB, in vitro, SPR, ELISA, FC, IF, IHC
Summary
Specifications
Antibody Isotype
IgG2a
Clone
Z22
Immunogen
Z22 was prepared by immunizing C57BL/6 mice with brominated poly(dG-dC).poly(dG-dC) complexed with methylated bovine serum albumin (BSA), and was selected for by ELISA.
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in EMSA, IB, in vitro, SPR, ELISA, FC, IF, IHC. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Target
Alternative Names
Z-DNA/Z-RNA; Z-DNA; Z-RNA
Citations
Publication ()
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