Triptolide Standard

Target

Triptolide

Nature

Synthetic

Cas.No

38748-32-2

Molecular Weight

360.4 g/mol

Purity

≥98%

Format

White to Off-White Solid

Storage

Store at -20°C

Introduction

Triptolide is a diterpenoid epoxide isolated from Tripterygium wilfordii, widely studied for its potent immunosuppressive, anti-inflammatory, and pro-apoptotic activities. It inhibits RNA polymerase II–mediated transcription, disrupts heat-shock responses, and modulates multiple signaling pathways including NF-κB and MAPK. Due to its strong cytotoxicity and molecular specificity, triptolide is commonly used as a tool compound in studies of cancer biology, inflammatory signaling, natural-product pharmacology, and apoptosis mechanisms.

Keywords

Triptolide; PG490; Tripterygium wilfordii polyglycoside active component; (1S,2R,4aS,6R,7R,8aR)-compound (common structural descriptor)