Inquiry Basket
Loading ......
Filter By Product Search for
FGF17
FGF17 Full Name
fibroblast growth factor 17
FGF17 Introduction
FGF17 is a member of the fibroblast growth factor family that plays a critical role in embryonic brain development, particularly in the patterning of the midbrain-hindbrain boundary. As a secreted signaling molecule, FGF17 functions through autocrine or paracrine mechanisms to regulate cell proliferation, differentiation, and tissue morphogenesis during embryogenesis. In the developing brain, FGF17 is expressed at the midbrain-hindbrain boundary and is essential for the proper induction and patterning of cerebellar structures. Studies have shown that FGF17 deficiency leads to abnormal development of the midbrain and hindbrain regions, resulting in cerebellar malformations and associated neurological deficits. The protein signals through FGF receptors (FGFRs) to activate downstream pathways including MAPK/ERK and PI3K/AKT, which control cell fate decisions and tissue organization in the developing central nervous system.
Figure 1. Fgf17 gene structure. (Source: Oberholzer Z, et al. 2024)
Beyond its developmental roles, FGF17 has been implicated in several human diseases. Mutations in the FGF17 gene have been associated with congenital hypogonadotropic hypogonadism, a disorder characterized by insufficient sexual maturation due to defective secretion or action of gonadotropin-releasing hormone (GnRH). Additionally, altered FGF17 expression has been observed in certain cancers, although its precise role in oncogenesis remains to be fully elucidated. The protein's ability to regulate neural progenitor cell proliferation also suggests potential involvement in neurodevelopmental disorders. Given its critical functions in brain development and endocrine regulation, FGF17 represents a promising target for understanding developmental defects and potential therapeutic interventions in related disorders.
Alternate Names for FGF17
FGF17; fibroblast growth factor 17; HH20; FGF-13; FGF-17;
Loading ......
